Wrinkle Treatments Wrinkles mainly happen on the parts of the body that get the most sun exposure, including the face, neck, the backs of the hands, and the tops of the forearms. There are several ways to minimize the appearance of wrinkles and even remove them. Retinoids (tretinoin, Altreno, Retin-A, Renova). Among medical treatments, this is by far the most proven and effective way of bettering signs of aging such as uneven pigmentation, roughness, and wrinkling. At first, these medications may cause redness and peeling. Although this can be unpleasant, improvement comes when the peeling stops. Alpha-hydroxy acids. These are the so-called "fruit acids" and include glycolic and lactic acid. Preparations containing these fruit acids are quite safe and cause no more than...